5 Substances You Should Never Take While on Antidepressants


In recent years, the prevalence of mental health issues has led to an increase in the prescription of antidepressant medications. These medications can be highly effective in treating conditions such as depression and anxiety. However, it is essential to be aware of potential interactions that can occur when combining antidepressants with other substances. The following are five substances a person should never take while on antidepressants.

Marijuana and Antidepressants

People must understand the relationship between marijuana and antidepressants. Combining marijuana (cannabis) and antidepressants can potentially have adverse effects and interactions. Both marijuana and certain antidepressants can cause drowsiness and sedation. Combining the two may enhance these effects, leading to excessive sedation, impaired coordination, and an increased risk of accidents.

The effects of marijuana on mental health conditions like depression and anxiety are still being studied and vary from person to person. While some individuals may experience temporary relief from symptoms, others may find that marijuana exacerbates their depression or anxiety. This can be especially concerning if someone is taking antidepressants to manage these conditions.

Marijuana and antidepressants can both affect the levels of certain neurotransmitters in the brain. Combining them may lead to interactions that affect the effectiveness or side effects of either substance. For example, some antidepressants, such as selective serotonin reuptake inhibitors (SSRIs), can increase serotonin levels. When combined with marijuana, which may also affect serotonin levels, there is a potential for excessive serotonin activity (serotonin syndrome), which can be a serious condition.

Alcohol and Antidepressants

Mixing alcohol with antidepressants can be extremely dangerous. Both alcohol and antidepressants affect the central nervous system, and combining them can lead to increased drowsiness, impaired judgment, and even a higher risk of overdose. Alcohol can also counteract the positive effects of antidepressants, making the treatment less effective. The person will not see the desired level of relief when combing alcohol and their medications.

Over-the-Counter Medications

Certain over-the-counter medications can interact negatively with antidepressants. For example, medications containing pseudoephedrine, commonly found in decongestants, can raise blood pressure and potentially lead to a dangerous condition called serotonin syndrome when combined with certain types of antidepressants. Always consult with a healthcare professional before taking any over-the-counter medication while on antidepressants.

Herbal supplements

While natural supplements may seem harmless, they can still interact with antidepressants. St. John’s wort, a commonly used herbal supplement for mild depression, can interfere with the effectiveness of prescription antidepressants and increase the risk of side effects. Other herbal supplements like ginkgo biloba and kava can also have adverse effects when combined with antidepressants.

Prescription medications

It is crucial to inform a healthcare provider about all prescription medications being taken when starting antidepressant treatment. Certain medications, such as monoamine oxidase inhibitors (MAOIs), have significant interactions with many other drugs, including other antidepressants, pain medications, and certain antibiotics. Combining incompatible medications can lead to serious health risks, including serotonin syndrome, hypertensive crisis, or respiratory depression.

Always remember to consult with a healthcare provider or pharmacist if there are doubts or concerns about potential interactions between antidepressants and other substances. They can provide valuable guidance and ensure the person’s safety during the course of the treatment.

While antidepressants can greatly improve mental well-being, it is essential to exercise caution and avoid combining them with substances that can pose risks. Prioritizing safety and working closely with a healthcare provider will help ensure a successful and effective antidepressant therapy. Knowing the potential interactions ensures the patient gets the most from their treatment plan.

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